GAB1 and TNS3

Data Source:
BioGRID (pull down)

		GAB1	TNS3
Description		GRB2 associated binding protein 1	tensin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction	Cytosol Focal Adhesion
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Cytoskeleton Reorganization Response To Hepatocyte Growth Factor Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase B Signaling Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor
Pathways		PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants	MET interacts with TNS proteins
Drugs
Diseases
GWAS		Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Alcohol dependence symptom count ( 29460428) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Basal cell carcinoma ( 31174203 27539887) Birth weight ( 31043758) Colorectal cancer (diet interaction) ( 24743840) Diastolic blood pressure ( 27841878) Dimensional psychopathology (Positive) ( 29496196) Electroencephalogram traits ( 25387704) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Granulocyte count ( 27863252) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Insulin-like growth factors ( 21216879) Iris color (a* coordinate) ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pancreatic cancer ( 29422604) Prostate cancer ( 25217961) Pulse pressure ( 30224653 27841878 29403010) QRS duration ( 27659466) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		73 interacting genes: ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 LCK LYN MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 YES1	11 interacting genes: BCAR1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT MET PTK2 SRPK2
Entrez ID		2549	64759
HPRD ID		05116	08438
Ensembl ID		ENSG00000109458	ENSG00000136205
Uniprot IDs		Q13480 Q9HA84	Q68CZ2
PDB IDs		4QSY
Enriched GO Terms of Interacting Partners?
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