NIPAL4 and GJB1

Data Source:
BioGRID (two hybrid)

		NIPAL4	GJB1
Description		NIPA like domain containing 4	gap junction protein beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane
	Molecular Function	Protein Binding Magnesium Ion Transmembrane Transporter Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Magnesium Ion Transport Magnesium Ion Transmembrane Transport	Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport
Pathways		Miscellaneous transport and binding events	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Asthma ( 31959851)
Interacting Genes		15 interacting genes: ACKR2 CLDN7 CMTM2 COMT FFAR2 GJB1 GPR152 HHLA2 IL10RA LHFPL5 RNF185 RNF19B SSMEM1 TM4SF18 TRHR	57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6
Entrez ID		348938	2705
HPRD ID		19424	02367
Ensembl ID		ENSG00000172548	ENSG00000169562
Uniprot IDs		Q0D2K0	A0A654ICJ7 P08034
PDB IDs			1TXH 5KK9
Enriched GO Terms of Interacting Partners?
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