GJB1 and TMEM120B

Data Source:
BioGRID (two hybrid)

		GJB1	TMEM120B
Description		gap junction protein beta 1	transmembrane protein 120B
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane	Cellular_component Nuclear Inner Membrane Membrane Integral Component Of Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Molecular_function Ion Channel Activity Protein Binding
	Biological Process	Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport	Biological_process Ion Transmembrane Transport Fat Cell Differentiation Protein Heterooligomerization
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Blood protein levels ( 29875488) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 32888494 27863252) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	56 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15
Entrez ID		2705	144404
HPRD ID		02367	19119
Ensembl ID		ENSG00000169562	ENSG00000188735
Uniprot IDs		A0A654ICJ7 P08034	A0PK00
PDB IDs		1TXH 5KK9
Enriched GO Terms of Interacting Partners?
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