GJB1 and GPR25

Data Source:
BioGRID (two hybrid)

		GJB1	GPR25
Description		gap junction protein beta 1	G protein-coupled receptor 25
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport	G Protein-coupled Receptor Signaling Pathway
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly	G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Refractive error ( 32231278)
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	32 interacting genes: AQP6 ATP6V0C ATP6V0E1 BEST2 CNIH4 CREB3L1 CREB3L3 FATE1 GGT7 GJB1 IKBIP KASH5 LDLRAD1 LMNA MAP3K7 MFSD5 MMGT1 NAALADL2 PNMA1 RETN RHCG SHISAL1 SLC16A7 SLC35E3 SLCO4A1 STOM TMEM237 TMEM248 TMEM52B TPRA1 TSPAN12 VAPB
Entrez ID		2705	2848
HPRD ID		02367	03707
Ensembl ID		ENSG00000169562	ENSG00000170128
Uniprot IDs		A0A654ICJ7 P08034	O00155
PDB IDs		1TXH 5KK9
Enriched GO Terms of Interacting Partners?
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