KLHL38 and UBE3A

Data Source:
BioGRID (two hybrid)

		KLHL38	UBE3A
Description		kelch like family member 38	ubiquitin protein ligase E3A
Image		No pdb structure
GO Annotations	Cellular Component		Proteasome Complex Nucleus Cytosol
	Molecular Function	Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Atrial fibrillation ( 29892015) Carotid intima media thickness (mean) ( 31801372) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Heel bone mineral density ( 30598549) PR interval ( 32439900) QRS duration ( 30012220) Systolic blood pressure ( 30578418)	Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		88 interacting genes: ADAMTSL4 ADRA2C AGR2 ASB12 BHLHB9 BLZF1 C11orf1 CCDC33 CERCAM CFP CTAG1A CTAG1B CYSRT1 DMAC2L ECM1 FTO GOLGA6A GSC2 HDHD3 IKZF3 KLHL20 KRT27 KRT31 KRT34 KRT35 KRT38 KRT39 KRT40 KRT85 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-1 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-11 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LHX3 LHX4 MAGEA6 MDFI MEOX2 MGAT5B MKRN3 MORN3 NBPF19 NOTCH2NLA OIP5 PAX5 PBX4 PFDN5 PLSCR4 POF1B POU2AF1 RGS20 RSPO4 SLC15A2 SPRY4 TACC3 TADA2A TCF4 TEKT1 TEKT5 TENT5B TEPSIN TIMM10B TRAF1 TRIB3 TRIM42 TRIM54 TRIM69 TXNDC11 UBE3A USHBP1 WFDC5 WWOX YPEL3 ZNF341	125 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MARF1 MCM6 MCM7 MDM1 MDM2 MEOX2 NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446
Entrez ID		340359	7337
HPRD ID		19276	03375
Ensembl ID		ENSG00000175946	ENSG00000114062
Uniprot IDs		Q2WGJ6	Q05086 Q9H2G0
PDB IDs			1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19
Enriched GO Terms of Interacting Partners?
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