HTR2C and GPR37

Data Source:
BioGRID (two hybrid)

		HTR2C	GPR37
Description		5-hydroxytryptamine receptor 2C	G protein-coupled receptor 37
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		Serotonin receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Epicept NP-1 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS			Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: APBA1 ARRB2 ATP2B3 ATP6AP2 ATP6V0C C4orf3 CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MFSD14A MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		3358	2861
HPRD ID		02429	03992
Ensembl ID		ENSG00000147246	ENSG00000170775
Uniprot IDs		K9J958 P28335	O15354
PDB IDs		6BQG 6BQH
Enriched GO Terms of Interacting Partners?
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