HTR2C and TM9SF2

Data Source:
BioGRID (two hybrid)

		HTR2C	TM9SF2
Description		5-hydroxytryptamine receptor 2C	transmembrane 9 superfamily member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Endosome Cytoskeleton Integral Component Of Plasma Membrane Endosome Membrane Membrane Extracellular Exosome Postsynaptic Golgi Apparatus
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Protein Localization To Membrane
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Epicept NP-1 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS			Asthma ( 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		34 interacting genes: APBA1 ARRB2 ATP2B3 ATP6AP2 ATP6V0C C4orf3 CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MFSD14A MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1	4 interacting genes: AQP2 HTR2C RAB9A SMAD4
Entrez ID		3358	9375
HPRD ID		02429	09198
Ensembl ID		ENSG00000147246	ENSG00000125304
Uniprot IDs		K9J958 P28335	A0A024QYR8 Q99805
PDB IDs		6BQG 6BQH
Enriched GO Terms of Interacting Partners?
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