ALDOB and MAP2K4

Data Source:
BioGRID (two hybrid)

		ALDOB	MAP2K4
Description		aldolase, fructose-bisphosphate B	mitogen-activated protein kinase kinase 4
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GO Annotations	Cellular Component	Microtubule Organizing Center Cytosol Centriolar Satellite Extracellular Exosome	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding ATPase Binding Fructose-1-phosphate Aldolase Activity Fructose Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Fructose Metabolic Process Gluconeogenesis Glycolytic Process NADH Oxidation Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of ATPase Activity Canonical Glycolysis Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases		Hereditary fructose intolerance; Fructosemia
GWAS		Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010)	Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)
Interacting Genes		22 interacting genes: AGXT2 ALDOA APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2	43 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC
Entrez ID		229	6416
HPRD ID		01972	03213
Ensembl ID		ENSG00000136872	ENSG00000065559
Uniprot IDs		A0A024R145 P05062	P45985
PDB IDs		1QO5 1XDL 1XDM	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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