NUPR1 and PTMA

Data Source:
BioGRID (two hybrid)

		NUPR1	PTMA
Description		nuclear protein 1, transcriptional regulator	prothymosin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex Intercellular Bridge Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Acetyltransferase Activator Activity	Protein Binding Activating Transcription Factor Binding
	Biological Process	Acute Inflammatory Response Protein Acetylation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Protein Modification Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Negative Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Assembly Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Autophagosome Assembly Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Female Gonad Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Transcription, DNA-templated Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Offspring birth weight ( 31043758) Refractive error ( 32231278) Urinary metabolite levels in chronic kidney disease ( 31959995)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		16 interacting genes: ABCG8 ALDH1A1 EP300 KNSTRN MAPRE1 MPHOSPH6 MSL1 NPY5R PAXIP1 PTMA RANBP1 RPL41 SEC11A SET STX18 SYNCRIP	41 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17
Entrez ID		26471	5757
HPRD ID		17814	01778
Ensembl ID		ENSG00000176046	ENSG00000187514
Uniprot IDs		A0A024QZC4 O60356	P06454 Q53S24
PDB IDs			2L9I 2MNQ
Enriched GO Terms of Interacting Partners?
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