PTMA and PHB2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PTMA	PHB2
Description		prothymosin alpha	prohibitin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Mitochondrial Prohibitin Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Activating Transcription Factor Binding	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Apoptotic Process	Activation Of MAPK Activity Mitophagy Immunoglobulin Production Protein Import Into Nucleus Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Sister Chromatid Cohesion Activation Of Phospholipase C Activity Response To Wounding Cell Migration CD40 Signaling Pathway Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Induction By Virus Of Host Autophagy RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity Activation Of Protein Kinase C Activity
Pathways			Processing of SMDT1
Drugs			Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)	Glycated hemoglobin levels ( 28898252) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17	21 interacting genes: AFP AKT1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PRKCA PTEN PTMA RNF2 TEAD3 UPF2
Entrez ID		5757	11331
HPRD ID		01778	17843
Ensembl ID		ENSG00000187514	ENSG00000215021
Uniprot IDs		P06454 Q53S24	Q99623
PDB IDs		2L9I 2MNQ	6IQE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?