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PTMA and TERF2
Data Source:
BioGRID
(two hybrid)
PTMA
TERF2
Description
prothymosin alpha
telomeric repeat binding factor 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Nuclear Body
Mre11 Complex
Shelterin Complex
Axon Cytoplasm
Molecular Function
Protein Binding
Activating Transcription Factor Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Transcription, DNA-templated
Negative Regulation Of Apoptotic Process
Telomere Maintenance
In Utero Embryonic Development
RNA-dependent DNA Biosynthetic Process
Cell Cycle
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Positive Regulation Of Nitric-oxide Synthase Activity
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Beta-galactosidase Activity
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Exonuclease Activity
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
27863252
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Interacting Genes
41 interacting genes:
CASP3
CASP7
CCNA2
CCNB1
CDK1
CDK2
CDK4
CREBBP
EP300
ESR1
H1-1
H2AC14
H2BC21
H2BC8
H3-4
H3C14
H4C1
H4C14
HDAC1
HDAC2
HSPA1A
IL7R
KEAP1
KPNA2
KPNB1
NCOR1
NUP62
NUPR1
NUTF2
PCNA
PHB2
RAN
RCC1
SET
SIN3A
STAT3
TERF1
TERF2
TERF2IP
VIPR1
ZDHHC17
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
Entrez ID
5757
7014
HPRD ID
01778
03610
Ensembl ID
ENSG00000187514
ENSG00000132604
Uniprot IDs
P06454
Q53S24
Q15554
PDB IDs
2L9I
2MNQ
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
Enriched GO Terms of Interacting Partners
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