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PTMA and H2BC8
Data Source:
HPRD
(in vitro)
PTMA
H2BC8
Description
prothymosin alpha
H2B clustered histone 8
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Activating Transcription Factor Binding
DNA Binding
Protein Binding
Identical Protein Binding
Protein Heterodimerization Activity
Biological Process
Transcription, DNA-templated
Negative Regulation Of Apoptotic Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Protein Ubiquitination
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Copper
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
27863252
)
Interacting Genes
41 interacting genes:
CASP3
CASP7
CCNA2
CCNB1
CDK1
CDK2
CDK4
CREBBP
EP300
ESR1
H1-1
H2AC14
H2BC21
H2BC8
H3-4
H3C14
H4C1
H4C14
HDAC1
HDAC2
HSPA1A
IL7R
KEAP1
KPNA2
KPNB1
NCOR1
NUP62
NUPR1
NUTF2
PCNA
PHB2
RAN
RCC1
SET
SIN3A
STAT3
TERF1
TERF2
TERF2IP
VIPR1
ZDHHC17
7 interacting genes:
AP2M1
ESR1
PTMA
RAD51B
TGM2
UBR2
YWHAQ
Entrez ID
5757
8339
HPRD ID
01778
11897
Ensembl ID
ENSG00000187514
ENSG00000273802
Uniprot IDs
P06454
Q53S24
B2R4S9
P62807
PDB IDs
2L9I
2MNQ
5GT0
5KGF
6ACO
6C0W
6FML
6R0C
6RNY
6SE0
6SE6
6SEE
6SEF
6SEG
6UPK
6UPL
6X59
6X5A
6XJD
7A08
7JO9
7JOA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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