PSMC3IP and NOTCH2

Data Source:
BioGRID (two hybrid)

		PSMC3IP	NOTCH2
Description		PSMC3 interacting protein	notch receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	DNA Binding Nuclear Receptor Coactivator Activity	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Reciprocal Meiotic Recombination Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Stem Cell Population Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Growth Rate Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Proximal Tubule Development Glomerular Visceral Epithelial Cell Development Glomerular Capillary Formation Hepatocyte Proliferation Cholangiocyte Proliferation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Osteoclast Development
Pathways		Meiotic recombination	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases			Alagille syndrome Type II diabetes mellitus Hajdu-Cheney syndrome
GWAS		Colorectal or endometrial cancer ( 26621817) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 18372903 30054458 30297969)
Interacting Genes		20 interacting genes: AR AURKA BCAR3 BRMS1 CASP8 CHEK2 ERBB2 ESR1 ESR2 FGFR4 FZR1 NOTCH2 NR3C1 PIK3CA PSMC3 RB1CC1 RXRA TGFB1 THRB XRCC3	31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SMAD1 ST14
Entrez ID		29893	4853
HPRD ID		16362	02606
Ensembl ID		ENSG00000131470	ENSG00000134250
Uniprot IDs		A0A158RUX1 K7ERB6 Q9P2W1	Q04721 Q6IQ50 Q9UFD5
PDB IDs			2OO4 5MWB
Enriched GO Terms of Interacting Partners?
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