TRIM29 and HDAC9

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		TRIM29	HDAC9
Description		tripartite motif containing 29	histone deacetylase 9
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Adherens Junction	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Activity (H4-K16 Specific) Histone Deacetylase Binding Metal Ion Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Response To Amphetamine Inflammatory Response Heart Development Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Cholesterol Homeostasis Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Lipoprotein Lipase Activity Regulation Of Striated Muscle Cell Differentiation Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Histone H4-K16 Deacetylation
Pathways		Interferon gamma signaling	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway
Drugs			Valproic acid Belinostat Panobinostat
Diseases
GWAS		Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)	Abdominal aortic calcification levels ( 31659325) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid angiopathy ( 25188341) Coronary artery disease ( 32469254 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Cortical surface area (visual PC2) ( 32198502) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Fasting blood glucose ( 31217584) Height ( 31562340) Iris color (b* coordinate) ( 30895295) Ischemic stroke ( 26708676 29531354) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke ( 28265093 24262325) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Late-onset Alzheimer's disease ( 27770636) Loneliness ( 27629369) Male-pattern baldness ( 22693459 27182965 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 31628463) Moderate-to-late spontaneous preterm birth ( 31194736) Monobrow ( 27182965) Moyamoya disease ( 29273593) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 26488411 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518) Reading disability ( 32108986) Reasoning ( 29907492) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Response to lithium treatment in bipolar disorder ( 26806518) Resting-state electroencephalogram vigilance ( 29703947) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652 26089329 29531354) Stroke (ischemic) ( 23041239) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Systolic blood pressure ( 27841878 30487518) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 20848476) Zinc levels ( 26025379)
Interacting Genes		54 interacting genes: ACTN3 ANKS1A ATM CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM	29 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4-16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16
Entrez ID		23650	9734
HPRD ID		10280	05944
Ensembl ID		ENSG00000137699	ENSG00000048052
Uniprot IDs		A0A024R3J1 B7Z5V5 B7Z8U9 E9PRL4 Q14134	B7Z3P7 Q9UKV0
PDB IDs		2CSV
Enriched GO Terms of Interacting Partners?
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