TRIM29 and FBXL19

Data Source:
BioGRID (two hybrid)

		TRIM29	FBXL19
Description		tripartite motif containing 29	F-box and leucine rich repeat protein 19
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GO Annotations	Cellular Component	Lysosome Adherens Junction	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus	Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Protein Demethylation Histone Demethylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Interferon gamma signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)	Diastolic blood pressure ( 28135244 27841878) Mean corpuscular volume ( 27863252) Psoriasis ( 25903422 20953189 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878)
Interacting Genes		54 interacting genes: ACTN3 ANKS1A ATM CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM	13 interacting genes: ABI1 ABI2 CBFA2T2 CREBBP DGAT2L6 EFHC2 NCK2 PSME3 RPRM SORBS3 TMEM239 TRIM27 TRIM29
Entrez ID		23650	54620
HPRD ID		10280	12366
Ensembl ID		ENSG00000137699	ENSG00000099364
Uniprot IDs		A0A024R3J1 B7Z5V5 B7Z8U9 E9PRL4 Q14134	H3BVB1 Q6PCT2
PDB IDs		2CSV	6ASB
Enriched GO Terms of Interacting Partners?
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