TRIM29 and MSH2

Data Source:
BioGRID (pull down)

		TRIM29	MSH2
Description		tripartite motif containing 29	mutS homolog 2
Image
GO Annotations	Cellular Component	Lysosome Adherens Junction	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin
Pathways		Interferon gamma signaling	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Ovarian cancer
GWAS		Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)	Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		54 interacting genes: ACTN3 ANKS1A ATM CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM	48 interacting genes: AKT1 ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MSH3 MSH6 MYC PCNA PPP3R2 RAD1 RAD9A RPA4 RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510
Entrez ID		23650	4436
HPRD ID		10280	00389
Ensembl ID		ENSG00000137699	ENSG00000095002
Uniprot IDs		A0A024R3J1 B7Z5V5 B7Z8U9 E9PRL4 Q14134	A0A2R8Y6P0 P43246
PDB IDs		2CSV	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?