TSPO2 and FCGR1A

Data Source:
BioGRID (two hybrid)

		TSPO2	FCGR1A
Description		translocator protein 2	Fc fragment of IgG receptor Ia
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Organelle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Cholesterol Binding	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding
	Biological Process	Intracellular Cholesterol Transport Lipid Droplet Organization Enucleate Erythrocyte Differentiation Amino Acid Import Across Plasma Membrane Import Across Plasma Membrane	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways			Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS		Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866)
Interacting Genes		58 interacting genes: AHNAK2 AQP6 ARL13B ASGR2 ASZ1 BIK CD53 CD69 CD79A CERS4 CLDN4 CNR2 COL4A5 CPLX4 CREB3L1 DKK4 EBP EFNA5 EMP1 ERGIC3 ERP29 FCER1G FCGR1A FFAR2 FNDC9 FXYD3 GGT7 GJB5 GPR152 GPR42 IGFBP5 KCNJ6 KLRC1 LRRC59 MAL MARCHF2 MFF MFSD6 MS4A1 PDZK1IP1 PLEKHO1 PSCA RELL2 RETREG3 RPRM SLC10A1 SLC10A6 SLC16A2 SLC34A2 SLC41A3 SLC7A1 SPAG4 STOM SYT2 TMEM140 TMEM54 TMEM80 VSIR	30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		222642	2209
HPRD ID		16569	00904
Ensembl ID		ENSG00000112212	ENSG00000150337
Uniprot IDs		Q5TGU0	P12314
PDB IDs			3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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