FCGR1A and LILRB2

Data Source:
HPRD (in vitro)

		FCGR1A	LILRB2
Description		Fc fragment of IgG receptor Ia	leukocyte immunoglobulin like receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	Adaptive Immune Response Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Learning Or Memory Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of Protein Dephosphorylation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Neutrophil Degranulation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interleukin-10-mediated Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Postsynaptic Density Organization Negative Regulation Of T Cell Costimulation Regulation Of Dendritic Cell Differentiation
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) HDL cholesterol ( 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lactate dehydrogenase levels ( 29403010) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B	7 interacting genes: FCGR1A HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6
Entrez ID		2209	10288
HPRD ID		00904	11994
Ensembl ID		ENSG00000150337	ENSG00000131042
Uniprot IDs		P12314	A2IXV5
PDB IDs		3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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