FCGR1A and CD163

Data Source:
BioGRID (two hybrid)

		FCGR1A	CD163
Description		Fc fragment of IgG receptor Ia	CD163 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding	Scavenger Receptor Activity Protein Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	Receptor-mediated Endocytosis Acute-phase Response
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis	Scavenging of heme from plasma CD163 mediating an anti-inflammatory response
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan	Tetrachlorodecaoxide
Diseases
GWAS			Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 29083408)
Interacting Genes		30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B	5 interacting genes: CSNK2B FCGR1A HP MYH9 PRKCA
Entrez ID		2209	9332
HPRD ID		00904	05708
Ensembl ID		ENSG00000150337	ENSG00000177575
Uniprot IDs		P12314	Q86VB7
PDB IDs		3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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