FCGR1A and FCAR

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		FCGR1A	FCAR
Description		Fc fragment of IgG receptor Ia	Fc fragment of IgA receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding	IgA Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity	Immune Response Neutrophil Degranulation
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis	Neutrophil degranulation
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS			Blood protein levels ( 28240269) Ulcerative colitis ( 28067908)
Interacting Genes		30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B	6 interacting genes: CD79A FCGR1A LYN OSCAR PILRA PPP2CA
Entrez ID		2209	2204
HPRD ID		00904	00914
Ensembl ID		ENSG00000150337	ENSG00000186431
Uniprot IDs		P12314	A0A024R4N4 A0A024R4R4 P24071
PDB IDs		3RJD 4W4O 4X4M 4ZNE	1OVZ 1OW0 1UCT
Enriched GO Terms of Interacting Partners?
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