EMP3 and GJB1

Data Source:
BioGRID (two hybrid)

		EMP3	GJB1
Description		epithelial membrane protein 3	gap junction protein beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane
	Molecular Function	Protein Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	Cell Death Bleb Assembly	Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport
Pathways			Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes		43 interacting genes: AQP6 CD79A CLDN2 CLDN7 CREB3L1 CREM EDA ELOVL7 ERGIC3 FAM210B FNDC9 GJA5 GJB1 GPA33 GPR61 IFNGR2 IL3RA KIR3DL3 KLRC1 LDLRAD1 LEUTX LHFPL5 LRRC4C LYVE1 MR1 MS4A3 MUC1 OPRM1 P2RX7 PLEKHB2 RMDN3 SAR1A SECTM1 SIGLECL1 SLAMF8 SLC30A2 SLC35C2 SMIM3 SPACA1 TM4SF18 TMX2 TSPAN12 VSIG1	57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6
Entrez ID		2014	2705
HPRD ID		18514	02367
Ensembl ID		ENSG00000142227	ENSG00000169562
Uniprot IDs		A0A024QZF8 P54852	A0A654ICJ7 P08034
PDB IDs			1TXH 5KK9
Enriched GO Terms of Interacting Partners?
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