ELAVL1 and GJB3

Data Source:
BioGRID (two hybrid)

		ELAVL1	GJB3
Description		ELAV like RNA binding protein 1	gap junction protein beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Cytoplasm Gap Junction Connexin Complex Integral Component Of Membrane Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Import Into Nucleus Posttranscriptional Gene Silencing Regulation Of MRNA Stability Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance	In Utero Embryonic Development Placenta Development Cell-cell Signaling Spermatogenesis Skin Development Transmembrane Transport Cellular Response To Retinoic Acid
Pathways		HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway	Gap junction assembly
Drugs
Diseases			Erythrokeratodermia variabilis Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Blood protein levels ( 28240269)	Intraocular pressure ( 30591961) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		37 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VCP VEGFA XIAP	15 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1
Entrez ID		1994	2707
HPRD ID		16025	04505
Ensembl ID		ENSG00000066044	ENSG00000188910
Uniprot IDs		Q15717	A0A654ICK0 O75712
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?
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