ELAVL1 and C12orf75

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		ELAVL1	C12orf75
Description		ELAV like RNA binding protein 1	chromosome 12 open reading frame 75
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Import Into Nucleus Posttranscriptional Gene Silencing Regulation Of MRNA Stability Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Alzheimer's disease biomarkers ( 23419831) Carotid plaque burden ( 28282560) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Mild to moderate chronic kidney disease ( 31178898) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Systolic blood pressure ( 30224653)
Interacting Genes		37 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VCP VEGFA XIAP	2 interacting genes: ELAVL1 REL
Entrez ID		1994	387882
HPRD ID		16025	17368
Ensembl ID		ENSG00000066044	ENSG00000235162
Uniprot IDs		Q15717	Q8TAD7
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?
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