EIF2B1 and TRIML2

Data Source:
BioGRID (two hybrid)

		EIF2B1	TRIML2
Description		eukaryotic translation initiation factor 2B subunit alpha	tripartite motif family like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Response To Retinoic Acid Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Polycystic ovary syndrome ( 25574032)
Interacting Genes		21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I	48 interacting genes: ABI2 BLOC1S2 CBY2 CCDC146 CCDC92 CCHCR1 CCNH CDR2 CTBP2 EIF2B1 EIF3M FAM90A1 FAM9C HGS ING5 ITGB3BP KRT15 KRT24 KRT27 KRT31 KRT34 KRT38 KRT75 MBD3L2 MBD3L3 MEOX1 MEOX2 NECAB2 NFKBID NUP62 PICK1 POLR1H POU6F2 SH2D4A STN1 SUMO2 SYCE2 TBC1D25 TCF4 TFIP11 TRIM54 TSEN54 TSG101 USHBP1 XAF1 ZBED1 ZBTB33 ZFHX3
Entrez ID		1967	205860
HPRD ID		09458	08696
Ensembl ID		ENSG00000111361	ENSG00000179046
Uniprot IDs		Q14232	B7ZLC3 Q8N7C3
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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