EIF2B1 and EPM2A

Data Source:
BioGRID (two hybrid)

		EIF2B1	EPM2A
Description		eukaryotic translation initiation factor 2B subunit alpha	EPM2A glucan phosphatase, laforin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Nucleus
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling
Pathways		Recycling of eIF2:GDP	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I	16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		1967	7957
HPRD ID		09458	06345
Ensembl ID		ENSG00000111361	ENSG00000112425
Uniprot IDs		Q14232	H0UI04 O95278
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z	4R30 4RKK
Enriched GO Terms of Interacting Partners?
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