HNRNPU and ZNF689

Data Source:
HPRD (in vivo)

		HNRNPU	ZNF689
Description		heterogeneous nuclear ribonucleoprotein U	zinc finger protein 689
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nucleoplasm Telomerase Holoenzyme Complex Centrosome Cell Surface Membrane Nuclear Matrix Nuclear Speck Midbody Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle RNA Polymerase II Transcription Regulator Complex Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing Cell Cycle Regulation Of Mitotic Cell Cycle Dosage Compensation By Inactivation Of X Chromosome Viral Process RNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Generic Transcription Pathway
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549)
Interacting Genes		38 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HNRNPH3 HSPB1 IL7R KAT2B NDN NDRG1 NEDD4 NR3C1 PIN1 POLR2A POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689	4 interacting genes: HNRNPF HNRNPU NCL TRIM28
Entrez ID		3192	115509
HPRD ID		04185	14009
Ensembl ID		ENSG00000153187	ENSG00000156853
Uniprot IDs		Q00839 Q96BA7	Q96CS4
PDB IDs		1ZRJ
Enriched GO Terms of Interacting Partners?
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