TRIM50 and KLHL2

Data Source:
BioGRID (two hybrid)

		TRIM50	KLHL2
Description		tripartite motif containing 50	kelch like family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	Protein Ubiquitination	Protein Ubiquitination Post-translational Protein Modification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		40 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SNAI1 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620	31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		135892	11275
HPRD ID		15566	09311
Ensembl ID		ENSG00000146755	ENSG00000109466
Uniprot IDs		B7ZLG2 Q2M204 Q86XT4	B4DFZ5 E9PEX9 O95198
PDB IDs			2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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