TRIM50 and L3MBTL2

Data Source:
BioGRID (two hybrid)

		TRIM50	L3MBTL2
Description		tripartite motif containing 50	L3MBTL histone methyl-lysine binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Chromatin Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding
	Biological Process	Protein Ubiquitination	Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		40 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SNAI1 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620	49 interacting genes: AMOTL2 BEND7 BHLHB9 BIVM CARD9 CCDC106 CCDC33 CEP76 EFHC2 EIF4ENIF1 FAM217B GAS8 GKAP1 GOLGA2 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829
Entrez ID		135892	83746
HPRD ID		15566	13954
Ensembl ID		ENSG00000146755	ENSG00000100395
Uniprot IDs		B7ZLG2 Q2M204 Q86XT4	A0A0S2Z5X6 Q969R5
PDB IDs			2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?
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