TRIM50 and ARHGAP45

		TRIM50	ARHGAP45
Description		tripartite motif containing 50	Rho GTPase activating protein 45
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Cytosol Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination	Intracellular Signal Transduction Neutrophil Degranulation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Rho GTPase cycle Neutrophil degranulation
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		40 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SNAI1 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620	9 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 TRIM50 ZUP1
Entrez ID		135892	23526
HPRD ID		15566	03097
Ensembl ID		ENSG00000146755	ENSG00000180448
Uniprot IDs		B7ZLG2 Q2M204 Q86XT4	B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619
PDB IDs			3D25 3FT3
Enriched GO Terms of Interacting Partners?
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