KLHL2 and TRIM50

Data Source:
BioGRID (two hybrid)

		KLHL2	TRIM50
Description		kelch like family member 2	tripartite motif containing 50
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Protein Ubiquitination
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	40 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SNAI1 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620
Entrez ID		11275	135892
HPRD ID		09311	15566
Ensembl ID		ENSG00000109466	ENSG00000146755
Uniprot IDs		B4DFZ5 E9PEX9 O95198	B7ZLG2 Q2M204 Q86XT4
PDB IDs		2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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