KLHL2 and TXNDC12

		KLHL2	TXNDC12
Description		kelch like family member 2	thioredoxin domain containing 12
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Protein Binding Peptide Disulfide Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Negative Regulation Of Cell Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	9 interacting genes: CAMLG DPF2 FKBP7 KLHL2 SGTA SGTB UBQLN1 UBQLN2 ZDHHC17
Entrez ID		11275	51060
HPRD ID		09311	11633
Ensembl ID		ENSG00000109466	ENSG00000117862
Uniprot IDs		B4DFZ5 E9PEX9 O95198	O95881
PDB IDs		2XN4 4CHB	1SEN 2K8V
Enriched GO Terms of Interacting Partners?
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