LRG1 and PJA1

Data Source:
BioGRID (enzymatic study)

		LRG1	PJA1
Description		leucine rich alpha-2-glycoprotein 1	praja ring finger ubiquitin ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm
	Molecular Function	Molecular_function Transforming Growth Factor Beta Receptor Binding Protein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Biological_process Response To Bacterium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutrophil Degranulation Positive Regulation Of Angiogenesis Brown Fat Cell Differentiation	Protein Ubiquitination Protein Catabolic Process
Pathways		Neutrophil degranulation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper
Diseases
GWAS			Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		2 interacting genes: FN1 PJA1	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		116844	64219
HPRD ID		10056	02335
Ensembl ID		ENSG00000171236	ENSG00000181191
Uniprot IDs		P02750 Q68CK4	Q8NG27
PDB IDs			2L0B
Enriched GO Terms of Interacting Partners?
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