CLNK and P4HA2

Data Source:
BioGRID (two hybrid)

		CLNK	P4HA2
Description		cytokine dependent hematopoietic cell linker	prolyl 4-hydroxylase subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein-containing Complex Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Death Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Electron Transport Chain
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Proline
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 33536424 28714469) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 33199917) Intraocular pressure ( 29617998) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	6 interacting genes: CLNK CREB3 FHL3 P4HB PRRC2A TNS4
Entrez ID		116449	8974
HPRD ID		14720	11862
Ensembl ID		ENSG00000109684	ENSG00000072682
Uniprot IDs		Q7Z7G1	O15460 Q05DA4
PDB IDs			6EVL 6EVM 6EVN 6EVO 6EVP
Enriched GO Terms of Interacting Partners?
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