NACC1 and SENP1

Data Source:
BioGRID (enzymatic study)

		NACC1	SENP1
Description		nucleus accumbens associated 1	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cell Junction Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Histone Deacetylase Binding	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Negative Regulation Of Transcription, DNA-templated	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway
Pathways			SUMO is proteolytically processed
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		19 interacting genes: BCOR C8orf33 EHHADH ELOA HDAC3 HDAC4 LGALS8 LSM3 PML POLR2L PRKCI PRPF18 PRPF3 SENP1 SENP2 TARDBP UBE2I UBTFL1 ZNF512B	22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID		112939	29843
HPRD ID		10692	07153
Ensembl ID		ENSG00000160877	ENSG00000079387
Uniprot IDs		A0A024R7E0 Q96RE7	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		3GA1 4U2N	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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