COPS5 and USP14

Data Source:
BioGRID (two hybrid)

		COPS5	USP14
Description		COP9 signalosome subunit 5	ubiquitin specific peptidase 14
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Perinuclear Region Of Cytoplasm	Proteasome Complex Nucleus Cytosol Plasma Membrane Cell Surface Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Metalloendopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity NEDD8-specific Protease Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Isopeptidase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Translation Translational Initiation Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion	Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Protein Phosphopantetheinylation Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Ub-specific processing proteases
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS
Interacting Genes		98 interacting genes: APCS ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 CACNA1C CD274 CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 DDO ERN1 ERRFI1 ESR1 F2RL1 GFER GFI1B GPS1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 ITGB2 JUN JUND LASP1 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	11 interacting genes: COPS5 CXCR4 FANCC SEM1 SPAG5-AS1 TRIM11 UBC USP15 USP21 USP28 XRCC6
Entrez ID		10987	9097
HPRD ID		06888	06279
Ensembl ID		ENSG00000121022	ENSG00000101557
Uniprot IDs		A0A024R7W9 Q92905	P54578
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I	2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?