COPS5 and MAP3K11

Data Source:
BioGRID (two hybrid)

		COPS5	MAP3K11
Description		COP9 signalosome subunit 5	mitogen-activated protein kinase kinase kinase 11
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Microtubule Membrane
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Metalloendopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity NEDD8-specific Protease Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Isopeptidase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Translation Translational Initiation Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Fostamatinib
Diseases
GWAS			Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969)
Interacting Genes		98 interacting genes: APCS ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 CACNA1C CD274 CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 DDO ERN1 ERRFI1 ESR1 F2RL1 GFER GFI1B GPS1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 ITGB2 JUN JUND LASP1 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	27 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6
Entrez ID		10987	4296
HPRD ID		06888	02502
Ensembl ID		ENSG00000121022	ENSG00000173327
Uniprot IDs		A0A024R7W9 Q92905	A0A024R5E6 Q16584
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I	5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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