USP14 and USP21

Data Source:
BioGRID (enzymatic study)

		USP14	USP21
Description		ubiquitin specific peptidase 14	ubiquitin specific peptidase 21
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Plasma Membrane Cell Surface Cytoplasmic Vesicle Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Protein Phosphopantetheinylation Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		Ub-specific processing proteases	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS
Interacting Genes		11 interacting genes: COPS5 CXCR4 FANCC SEM1 SPAG5-AS1 TRIM11 UBC USP15 USP21 USP28 XRCC6	59 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		9097	27005
HPRD ID		06279	05291
Ensembl ID		ENSG00000101557	ENSG00000143258
Uniprot IDs		P54578	Q9UK80
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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