COPS5 and CHUK

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		COPS5	CHUK
Description		COP9 signalosome subunit 5	component of inhibitor of nuclear factor kappa B kinase complex
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Metalloendopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity NEDD8-specific Protease Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Isopeptidase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Translation Translational Initiation Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Skeletal Muscle Contraction Protein Phosphorylation Inflammatory Response Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Rho Protein Signal Transduction Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Response To Acetate Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Reactive Oxygen Species TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Stress-activated MAPK Cascade Response To Cholecystokinin Interleukin-1-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Virus
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs			Aminosalicylic acid Mesalazine Sulfasalazine Acetylcysteine
Diseases			Cocoon syndrome
GWAS			Liver enzyme levels ( 18940312) Psoriasis ( 28537254) Type 2 diabetes ( 30054458)
Interacting Genes		98 interacting genes: APCS ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 CACNA1C CD274 CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 DDO ERN1 ERRFI1 ESR1 F2RL1 GFER GFI1B GPS1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 ITGB2 JUN JUND LASP1 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	81 interacting genes: AKT1 AKT2 AMBRA1 ATR BCL10 BCL3 BTRC CASP8 CDC37 CHEK1 COPS5 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 DCUN1D5 E2F4 EIF2AK2 ELP1 ERBIN ESR1 FKBP5 FOXO3 H3-4 H3C14 HSP90AA1 HSP90AB1 HTT IFIT5 IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP UBC UBE2E3 UBE2I UBE2N
Entrez ID		10987	1147
HPRD ID		06888	02811
Ensembl ID		ENSG00000121022	ENSG00000213341
Uniprot IDs		A0A024R7W9 Q92905	O15111
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I	3BRT 5EBZ 5TQW 5TQX 5TQY
Enriched GO Terms of Interacting Partners?
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