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USP14 and USP15
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study)
USP14
USP15
Description
ubiquitin specific peptidase 14
ubiquitin specific peptidase 15
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Extracellular Exosome
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Proteasome Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Modification-dependent Histone Binding
Lys48-specific Deubiquitinase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Protein Phosphopantetheinylation
Innate Immune Response
Regulation Of Chemotaxis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Protein Deubiquitination
Protein Phosphopantetheinylation
BMP Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathway-restricted SMAD Protein Phosphorylation
Protein K48-linked Deubiquitination
Positive Regulation Of RIG-I Signaling Pathway
Pathways
Ub-specific processing proteases
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Interacting Genes
11 interacting genes:
COPS5
CXCR4
FANCC
SEM1
SPAG5-AS1
TRIM11
UBC
USP15
USP21
USP28
XRCC6
55 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
DDX58
FHL1
GEMIN4
GOLGA2
GOLGA6A
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RNF126
RNF144B
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UBE2S
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
Entrez ID
9097
9958
HPRD ID
06279
05293
Ensembl ID
ENSG00000101557
ENSG00000135655
Uniprot IDs
P54578
Q9Y4E8
PDB IDs
2AYN
2AYO
5GJQ
6IIK
6IIL
6IIM
6IIN
6LVS
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
Enriched GO Terms of Interacting Partners
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