USP14 and TRIM11

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		USP14	TRIM11
Description		ubiquitin specific peptidase 14	tripartite motif containing 11
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Plasma Membrane Cell Surface Cytoplasmic Vesicle Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding	Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Protein Phosphopantetheinylation Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Neurogenesis Defense Response To Virus Negative Regulation Of Viral Release From Host Cell
Pathways		Ub-specific processing proteases	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS			Hip circumference (psychosocial stress interaction) ( 25271088) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)
Interacting Genes		11 interacting genes: COPS5 CXCR4 FANCC SEM1 SPAG5-AS1 TRIM11 UBC USP15 USP21 USP28 XRCC6	7 interacting genes: MED15 PAX6 RNF126 TRIM27 TRIM29 TRIM35 USP14
Entrez ID		9097	81559
HPRD ID		06279	07429
Ensembl ID		ENSG00000101557	ENSG00000154370
Uniprot IDs		P54578	Q96F44
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS
Enriched GO Terms of Interacting Partners?
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