SAP18 and DEF6

Data Source:
BioGRID (two hybrid)

		SAP18	DEF6
Description		Sin3A associated protein 18	DEF6 guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding	Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Height ( 18391951) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: DEF6 ERBB3 HDAC1 IKZF1 INCA1 NOL12 NTAQ1 POLE2 RBM39 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2	32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688
Entrez ID		10284	50619
HPRD ID		04256	10869
Ensembl ID		ENSG00000150459	ENSG00000023892
Uniprot IDs		O00422	Q9H4E7
PDB IDs		2HDE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?