DEF6 and ZNF688

Data Source:
BioGRID (two hybrid)

		DEF6	ZNF688
Description		DEF6 guanine nucleotide exchange factor	zinc finger protein 688
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm	Cellular_component Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Molecular_function Protein Binding Metal Ion Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Biological_process
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Height ( 18391951) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	111 interacting genes: ABI2 ANKRD11 BEND5 BLZF1 BOLA2 BOLA2B C1orf109 CADPS CALCOCO2 CARD9 CATSPER1 CBY2 CCDC102B CCDC136 CCDC33 CCDC57 CCNC CDKN2D CDR2L CEP44 CEP70 CEP72 CIB3 CRX DEF6 EHMT2 FAM90A1 FBXO7 FCHO1 FHL5 GEM GLYCTK GMPPA GOLGA2 GPANK1 GPRASP2 HMBOX1 HNRNPK HOMEZ HOXA1 HSF2BP IGFN1 IHO1 KHDRBS2 KHDRBS3 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-9 KRTAP12-2 KRTAP4-2 LDOC1 LMO1 LMO2 MAGED1 MDFI MEOX2 MID2 MIPOL1 MKRN3 MYOZ3 NCK2 NEK6 NFU1 NOTCH2NLA OSTF1 PCBD1 PFKFB1 PHF1 PIH1D2 PLSCR1 PNMA1 PNMA2 POLR1C PSMA3 PSMB1 PSTPIP1 RCOR3 REL RFX6 RINT1 RPGRIP1 SCNM1 SMARCB1 SPAG5 SSX2IP TADA2A TCEANC TCF12 TCF4 TCP11 TEKT4 TENT5B TLE5 TMCC2 TNS2 TRAF1 TRAF2 TRAF4 TRIM23 TRIM27 TRIP6 TTC19 USHBP1 WWP2 ZC4H2 ZGPAT ZNF330
Entrez ID		50619	146542
HPRD ID		10869	14070
Ensembl ID		ENSG00000023892	ENSG00000229809
Uniprot IDs		Q9H4E7	A0A024QZB6 A0A0S2Z633 P0C7X2
PDB IDs
Enriched GO Terms of Interacting Partners?
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