DEF6 and RAPGEF4

Data Source:
BioGRID (two hybrid)

		DEF6	RAPGEF4
Description		DEF6 guanine nucleotide exchange factor	Rap guanine nucleotide exchange factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Small GTPase Binding
	Biological Process		G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Catalytic Activity Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Height ( 18391951) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469) White blood cell count ( 32888494)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	13 interacting genes: ATXN1 BMERB1 DEF6 LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		50619	11069
HPRD ID		10869	06929
Ensembl ID		ENSG00000023892	ENSG00000091428
Uniprot IDs		Q9H4E7	B7Z278 Q8WZA2
PDB IDs
Enriched GO Terms of Interacting Partners?
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