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CDKN1B and COPS5
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
CDKN1B
COPS5
Description
cyclin dependent kinase inhibitor 1B
COP9 signalosome subunit 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Intracellular Membrane-bounded Organelle
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Synaptic Vesicle
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin Binding
Protein-containing Complex Binding
Chaperone Binding
Transcription Coactivator Activity
Translation Initiation Factor Activity
Metalloendopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
NEDD8-specific Protease Activity
Enzyme Binding
Macrophage Migration Inhibitory Factor Binding
Metal Ion Binding
Isopeptidase Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Negative Regulation Of Kinase Activity
Negative Regulation Of Phosphorylation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Cellular Response To Lithium Ion
Mitotic Cell Cycle Arrest
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Translation
Translational Initiation
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of IRE1-mediated Unfolded Protein Response
Exosomal Secretion
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Diseases
Prostate cancer
GWAS
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
31562322
29892016
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Interacting Genes
73 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE1
CCNE2
CDC34
CDK1
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL1
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RBX1
RCHY1
RNF123
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2I
UBE2L3
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
98 interacting genes:
APCS
ARFGAP1
ATM
ATRN
BCL2L14
BCL3
BRD4
BRSK2
CACNA1C
CD274
CD93
CDKN1B
CENPT
CHUK
COPS2
COPS3
COPS4
COPS6
COPS7A
COPS7B
COPS8
COPS9
CUL1
CUL2
CUL3
CUL4A
CUL5
DDB1
DDO
ERN1
ERRFI1
ESR1
F2RL1
GFER
GFI1B
GPS1
GTPBP3
HAND2
HIF1A
HNF4A
HNF4G
HTR6
ITGB2
JUN
JUND
LASP1
MAP2K2
MAP3K11
MAP3K3
MAP3K7
MAP4K3
MAP4K5
MAPK14
MAPRE1
MAX
MDC1
MDM2
MEF2C
MEF2D
MIF
MTRES1
MYG1
NCOA1
NEDD8
NFKB1
NR4A2
NR4A3
OPRM1
PEA15
PGR
PLAC8
PPARG
PPOX
PPP1CC
PRDX2
PRKD1
PTGS2
RAD1
RAD9A
RNF139
RORA
S100A7
SHANK3
SHISA5
SMAD2
SMAD4
SMAD5
SPP1
SREBF2
TOP2A
TP53
TXN
TYK2
UCHL1
USP14
VTN
WNK1
YWHAG
Entrez ID
1027
10987
HPRD ID
02867
06888
Ensembl ID
ENSG00000111276
ENSG00000121022
Uniprot IDs
P46527
Q6I9V6
A0A024R7W9
Q92905
PDB IDs
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
4D10
4D18
4F7O
4WSN
5JOG
5JOH
5M5Q
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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