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CDKN1B and TSC2
Data Source:
HPRD
(in vivo)
CDKN1B
TSC2
Description
cyclin dependent kinase inhibitor 1B
TSC complex subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Intracellular Membrane-bounded Organelle
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin Binding
Protein-containing Complex Binding
Chaperone Binding
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Negative Regulation Of Kinase Activity
Negative Regulation Of Phosphorylation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Cellular Response To Lithium Ion
Mitotic Cell Cycle Arrest
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Diseases
Prostate cancer
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
31562322
29892016
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
73 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE1
CCNE2
CDC34
CDK1
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL1
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RBX1
RCHY1
RNF123
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2I
UBE2L3
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
44 interacting genes:
AKT1
AKT2
AKT3
CALM1
CBY2
CCND1
CDKN1B
ESR1
FBXL6
FBXW5
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
NEK1
PAM
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPS6KA1
SFN
SMAD2
SMAD3
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
1027
7249
HPRD ID
02867
01850
Ensembl ID
ENSG00000111276
ENSG00000103197
Uniprot IDs
P46527
Q6I9V6
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
PDB IDs
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
Enriched GO Terms of Interacting Partners
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