CDKN1B and CCNB1

Data Source:
HPRD (in vitro)

		CDKN1B	CCNB1
Description		cyclin dependent kinase inhibitor 1B	cyclin B1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Intracellular Membrane-bounded Organelle	Cyclin-dependent Protein Kinase Holoenzyme Complex Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Cytosol Membrane Cyclin B1-CDK1 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin Binding Protein-containing Complex Binding Chaperone Binding	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Cellular Response To Lithium Ion Mitotic Cell Cycle Arrest Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Response To Drug Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerisation of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2
Drugs
Diseases		Prostate cancer
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 31562322 29892016) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)
Interacting Genes		73 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CDC34 CDK1 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL1 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RBX1 RCHY1 RNF123 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2I UBE2L3 UBE3A UCHL1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	59 interacting genes: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC34 CDC6 CDK1 CDKN1A CDKN1B CDT1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 MAP4 MEF2C MOK OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PRKDC PRKN PTCH1 PTMA RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2C UBE2D2 UBE2N UBE2S UBE3C UBE3D XIAP
Entrez ID		1027	891
HPRD ID		02867	00454
Ensembl ID		ENSG00000111276	ENSG00000134057
Uniprot IDs		P46527 Q6I9V6	P14635
PDB IDs		1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G	2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4
Enriched GO Terms of Interacting Partners?
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