SPRY1 and GNE

Data Source:
BioGRID (two hybrid)

		SPRY1	GNE
Description		sprouty RTK signaling antagonist 1	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		EGFR downregulation	Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM) Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS		Apolipoprotein B levels ( 32203549) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		83 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837	65 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16
Entrez ID		10252	10020
HPRD ID		06782	04825
Ensembl ID		ENSG00000164056	ENSG00000159921
Uniprot IDs		O43609	Q9Y223
PDB IDs			2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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