GNE and KPRP

Data Source:
BioGRID (two hybrid)

		GNE	KPRP
Description		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	keratinocyte proline rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Extracellular Exosome
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding	Protein Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM) Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)	Asthma ( 31619474) Psoriasis ( 25854761)
Interacting Genes		65 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16	108 interacting genes: AKAP8L ANKS1A ATG9A BTC C19orf54 CATSPER1 CCDC57 CES1 CKS1B CLCNKA CNFN CNNM3 COL8A1 CREB5 CYSRT1 DARS1-AS1 DMRT3 DYRK1A EIF3E ESR2 FAM221B FAM72B FBXO17 FCHO1 FHL2 FHL3 FRS3 GNE GRAP2 GRB2 GUCD1 HCK HEXIM2 HNRNPF HOXA1 HOXC8 HSD3B7 ITGB4 ITIH6 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 LCE3C LCE3D LCE3E LIMS1 LMO2 LNX1 MAPKBP1 MEOX2 MGAT5B MIIP MLH1 NBPF19 NCK2 NID2 NOTCH2NLA NPBWR2 NR4A3 NTN4 NUFIP2 OTX1 PDGFRB PHLDA1 PLA2G10 PLSCR4 POU4F2 PPIL1 PPP1R32 RANBP3 RBP3 RGL2 RNF38 SEMA3B SH3KBP1 SLC15A2 SPRED2 SPRY1 SPRY3 STK16 TEKT4 TFAP2D TNS2 TRIM42 TRIP6 UBASH3A UBASH3B VGLL3 VWC2 ZNF587
Entrez ID		10020	448834
HPRD ID		04825	18838
Ensembl ID		ENSG00000159921	ENSG00000203786
Uniprot IDs		Q9Y223	Q5T749
PDB IDs		2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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