SPRY1 and R3HDM2

Data Source:
BioGRID (two hybrid)

		SPRY1	R3HDM2
Description		sprouty RTK signaling antagonist 1	R3H domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Nucleus
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		EGFR downregulation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)	Apolipoprotein B levels ( 32203549) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163 31015462) Glomerular filtration rate (creatinine) ( 28452372) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32203549 32154731) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 20884846 31578528) Urate levels in overweight individuals ( 25811787)
Interacting Genes		83 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837	26 interacting genes: ADAMTSL4 ATXN1 C1orf94 CYSRT1 FAM168A INCA1 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-3 KRTAP3-2 KRTAP4-12 MEI4 MGAT5B NBPF19 NOTCH2NLA RBPMS REL SPRY1 SPRY3 TRIM42
Entrez ID		10252	22864
HPRD ID		06782	13827
Ensembl ID		ENSG00000164056	ENSG00000179912
Uniprot IDs		O43609	A0A0U1RRA6 B5MCG9 Q9Y2K5
PDB IDs			1WHR
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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