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GNE and KRTAP1-3
Data Source:
BioGRID
(two hybrid)
GNE
KRTAP1-3
Description
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
keratin associated protein 1-3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytosol
Keratin Filament
Molecular Function
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
Protein Binding
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Structural Constituent Of Skin Epidermis
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Cell Adhesion
Carbohydrate Phosphorylation
Biological_process
Keratinization
Pathways
Sialic acid metabolism
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Keratinization
Drugs
Diseases
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM)
Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Interacting Genes
65 interacting genes:
ADAMTSL4
C22orf39
CFP
CRMP1
CYSRT1
ECM1
EGFL7
GRN
GTPBP3
HOXA1
KIAA1549
KPRP
KRT31
KRT34
KRT40
KRT83
KRT85
KRT86
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-3
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP3-1
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-4
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MGAT5B
NBPF19
NID2
NOTCH2NLA
PLA2G10
PRICKLE4
RIF1
SPRY1
SPRY2
SPRY3
SSC4D
TRIM27
TRIM42
TRIP6
TSPAN4
VWC2
WDR83
WWOX
ZBTB16
176 interacting genes:
ADAM12
AGA
ALDH3B1
ALPP
ATG9A
BCAM
BHLHE40
BMP7
BTC
C19orf25
C2orf68
CATSPER1
CELF5
CHIC2
CHRD
CHRNG
CLDN2
CMTM8
CNNM3
COA5
COL8A1
CRCT1
CREB5
CRH
CRY2
CTNNBIP1
CXCL16
CYHR1
CYP21A2
CYSRT1
DHRS1
DLGAP3
DMRT3
DOCK2
ECE1
FBXW5
GLP1R
GLRX3
GNE
GRAP2
GSTP1
HCK
HHEX
HHIPL1
HOXA1
HOXB9
HOXC8
HPCAL1
HSD3B7
IGSF8
IL10
IL16
INPP5D
INS
ITGB4
ITGB5
JOSD1
KLHL38
KPRP
KRTAP10-1
KRTAP10-11
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LONRF1
LRFN4
MAPKBP1
MOS
MTNR1A
MXD3
MXI1
MYPOP
NAXD
NECTIN2
NECTIN3
NID2
NMU
NPBWR2
NPDC1
NR1D2
NUFIP2
OLFM2
OTX1
P3H3
PDE9A
PDIA5
PHETA1
PHLDA1
PIGS
PLEKHN1
PRKAA2
PRKAB2
PRPF31
PSMA1
PTK7
PTPMT1
PVR
R3HDM2
RAMAC
RANBP3
RASD1
RPN1
RPS19BP1
SAPCD2
SDC3
SDCBP
SELENOM
SHFL
SLC13A5
SLC22A23
SLC23A1
SLC39A7
SLC43A2
SLC7A11
SMCP
SPINT1
SPRY1
STK16
SUSD6
TACSTD2
TCAF1
TFAP2D
TGFB1
THAP7
TNS2
UNC119
UTP23
UXT
VASN
VSTM4
WNT11
XCL2
YIPF3
YY1
ZDHHC1
ZNF330
ZNF414
ZNF417
ZNF440
ZNF446
ZNF497
ZNF587
ZNF696
ZNF764
ZNF786
ZNF837
Entrez ID
10020
81850
HPRD ID
04825
12305
Ensembl ID
ENSG00000159921
ENSG00000221880
Uniprot IDs
Q9Y223
Q8IUG1
PDB IDs
2YHW
2YHY
2YI1
3EO3
4ZHT
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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